![]() ![]() Therefore, the active phytochemicals identified in A. muricata extract in downregulating anti -apoptotic and several genes involved in the pro-cancer metabolic pathways and decreasing the expression of proteins involved in cell invasion and metastasis while upregulating proapoptotic genes and genes involved in the destruction of cancer cells. Additionally, this review highlights the molecular mechanism of the role of A. muricata extract against various types of cancer, modulation of cellular proliferation and necrosis, and bioactive metabolites responsible for various pharmacological activities along with their ethnomedicinal uses. ![]() The most prevalent phytochemical components identified and isolated from this plant are alkaloids, phenols, and acetogenins. muricata has been identified to have promising compounds that could potentially be utilized for the treatment of cancer. Annona muricata is a member of the family Annonaceae and is familiar for its medicinal properties. Medicinal plants are universally acknowledged as the cornerstone of preventative medicine and therapeutic practices. Consequently, patients are looking for alternatives to traditional cancer treatments such as surgery, chemotherapy, and radiotherapy as a replacement. ![]() The ongoing rise in the number of cancer cases raises concerns regarding the efficacy of the various treatment methods that are currently available. ![]()
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